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Pfizer Inc. (PFE)

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  • J
    Joseph
    $ONTX conversation
    Hi everyone! I don’t usually post on here but I feel this stock needs an exception! I am extremely bullish on this one but as always make sure to do your DD. This could be an incredible play next week and as a long term hold:
    In AH:
    706,000 shares acquired by Fruchtman Steven M (President, Chief Executive Off), reported in a new form 4 filed with the SEC $ONTX newsfilter.io/articles/4-for…
    208,000 shares acquired by Oler Abraham N. (SVP Corp Dev & Gen Counsel), reported in a new form 4 filed with the SEC $ONTX newsfilter.io/articles/4-for…
    Company executives buying their own stock = gains. It’s as simple as that.
    Last time i saw insider loading 6 figures worth of shares was Kirkland $KIRK at .80 cents during crash of the market crash in march / april multiple execs loaded huge. Go figure, the stock is now trading a year later at 26 dollars.
    $ONTX has better results then $PFE drug which is already on the market
    - ONTX treatment can potentially KILL the cancer cells.
    - ONTX treatment inhibits metastasis (cancer spreading) MORE EFFICIENTLY than Pfizer's treatment
    Oral Rigosertib there is nothing in the market like this. Kras technology is slam dunk for inhibiting oncogene expressions. People go in remission and stay in remission forever!
    Showing how their ON 123300 third-generation multi-kinase inhibitor, currently in Phase 1 US/China trials, is effectively inhibiting growth of cancer cell lines that are resistant to PALBOCICLIB (a currently approved inhibitor)... see page/slide #12 showing how ON 123300 is significantly better than Palbociclib in reducing Breast cancer, Prostate cancer, and Ovarian cancer cells.... I would love to have research data showing that kind of difference in my own research (I'm a research microbiologist, un-related to cancer research, but I use graph presentations all the time).
    It’s a stock that could literally revolutionise cancer treatment and obviously everyone should do their dd but just thought I’d post this here x As someone who has been trading for over 20 years and with a current portfolio value of 480000 I will set out 3 price targets:
    Short term: 3/4 dollars
    Medium term: 5-8 dollars
    Long term: 15-20 dollars but can see it being even more than this if their cancer drugs become used worldwide.
    https://seekingalpha.com/.../4407514-onconova...
    https://player.vimeo.com/video/514070475
  • S
    Shaw
    Many of us would had committed partial suicide if $PFE had no dividend ! Which soothes the “lost” part. I ain’t seeing this dead drug raising anytime sooner ! But I am still LONG cuz of yields 🤑
  • U
    US Stock & Inflation PUMPING
    $^IXIC conversation
    INFLATION IS SKYROCKETING! THE FED MUST RAISE THE RATES!
    The US Stocks are EXTREMELY OVERVALUED and OVERBOUGHT!
    SELL ALL US Stocks in this TULIP MANIA BUBBLE! The Valuations are ABSURD and IMPOSSIBLE TO JUSTIFY!
    INFLATION IS SKYROCKETING as the FED continues to PUMP the Price of everything, stocks, oil, gold, home, land, commodities, utilities, food prices and everything!
    The World Economy is Collapsing, people are starving, but the US Market Makers are too busy in printing money and PUMPING the Stock prices Artificially to make insiders trillionaire without working!
    Enjoy Free Capital Gains in the US Stock Market while the Corporate Revenues are tanking and the Economy is Collapsing! US Stock Market is a “GET QUICK RICH” Scheme!
    Dow Jones Industrial Average (^DJI) was 17,000 in 2016, with better economic fundamentals and higher corporate earnings. However, thanks to the Collapsing Economy, Coronavirus Pandemic, Tanking Corporate revenues and earnings, Skyrocketing unemployment, Trade Wars, Record INFLATION levels, and Heavy Stock Dilutions, Dow Jones Industrial Average (^DJI) BUBBLE has almost Doubled!
    S&P 500 (^GSPC) was at 1600.00 with better fundamentals and higher corporate earnings in 2016. Now it is sitting at ABSURD 3800.00 with TERRIBLE Fundamentals, Collapsing Economy, HEAVIER Corporate and National Debt and way lower corporate revenues and earnings!
    The World Countries are refusing to accept the US Dollar as international reserve currency due to the HEAVY Dollar PRINTING!
    US Stocks are INSANELY OVERVALUED and OVERBOUGHT! US Stock Market is a MEGA BUBBLE right now!!!
    $AMD $NVDA $AMZN $AAPL $SQ $SHOP $SNAP $TWLO $CRM $ROKU $ADBE $DB $BAC $JPM $MS $GS $TWTR $TSLA $IBM $INTC $MSFT $GOOG $LMT $BA $TXN $NXPI $LRCX $NKE $DIS $EBAY $X $MA $V $S $T $F $GM $NFLX $CSCO $CAT $MMM $SBUX $TGT $WMT $ATVI $EA $TTWO $MCD $AVGO $JNJ $BIDU $BZUN $BABA $MU $AMAT $QCOM $WFC $BBBY $PFE $GE $WDC $BLK $KO $UA $ABBV $GILD $BB $ORCL $RH $KEM $IQ $GRPN $PYPL $MA $MOMO $JD $WBA $CVS $FB $W $BBY $SKX $FL $EFX $ETSY $W $UNH $SAP $GPRO $KHC $DPZ $PEP $LYFT $UBER $BYND $ZM $OLED $XOM $CVX $DAL $UAL $AAL $LUV $SAVE $AXP $SPCE $NCLH $CCL $NKLA $NIO $ZM $XPEV $QS
    https://finance.yahoo.com/quote/%5ETNX?p=%5ETNX
    Find the latest information on CBOE Interest Rate 10 Year T No (^TNX) including data, charts, related news and more from Yahoo Finance
    Find the latest information on CBOE Interest Rate 10 Year T No (^TNX) including data, charts, related news and more from Yahoo Finance
    finance.yahoo.com
  • C
    CA-ND-MN
    $ACRX conversation
    WHY DSUVIA over say $TRVN IV Oli or $PFE Morphine both invasive pain medications; AVOID IVs, w/ DSUVIA the world's only NON INVASIVE & RAPID Acute Pain medication in the WORLD. IV risks:
    - "Deep vein thrombosis is one type of dangerous blood clot that IV treatment can cause."
    - "If air gets into the syringe or the IV medication bag and the line runs dry, air bubbles can enter your vein. These air bubbles can then travel to your heart or lungs and block your blood flow. An air embolism can cause severe problems such as heart attack or stroke."
    - "Infection can occur at the injection site."
    - "A vein can be damaged during injection or by the use of an IV catheter line. This can cause infiltration. When this occurs, medication leaks into surrounding tissue instead of going into the bloodstream. Infiltration can cause tissue damage."
    - "IV's can cause vein damage by way of misplacement, duration of the IV within the venous system, or by the nature of medication in which they are delivering."
    - "IV bolus medications may cause a sudden drop in blood pressure or heart rate, or hives may result."
  • N
    Nasdaq Composite PONZI SCHEME
    $^FTSE conversation
    Who will bear the Loss when the Market starts to Lock in the Capital Gains in this MASSIVE STOCK BUBBLE?!
    SELL ALL US Stocks in this TULIP MANIA BUBBLE! The Valuations are ABSURD and IMPOSSIBLE TO JUSTIFY!
    INFLATION IS SKYROCKETING as the FED continues to PUMP the Price of everything, stocks, oil, gold, home, land, commodities, utilities, food prices and everything!
    The World Economy is Collapsing, people are starving, but the US Market Makers are too busy in printing money and PUMPING the Stock prices Artificially to make insiders trillionaire without working!
    Enjoy Free Capital Gains in the US Stock Market while the Corporate Revenues are tanking and the Economy is Collapsing! US Stock Market is a “GET QUICK RICH” Scheme!
    Dow Jones Industrial Average (^DJI) was 17,000 in 2016, with better economic fundamentals and higher corporate earnings. However, thanks to the Collapsing Economy, Coronavirus Pandemic, Tanking Corporate revenues and earnings, Skyrocketing unemployment, Trade Wars, Record INFLATION levels, and Heavy Stock Dilutions, Dow Jones Industrial Average (^DJI) BUBBLE has almost Doubled!
    S&P 500 (^GSPC) was at 1600.00 with better fundamentals and higher corporate earnings in 2016. Now it is sitting at ABSURD 3700.00 with TERRIBLE Fundamentals, Collapsing Economy, HEAVIER Corporate and National Debt and way lower corporate revenues and earnings!
    The World Countries are refusing to accept the US Dollar as international reserve currency due to the HEAVY Dollar PRINTING!
    US Stocks are INSANELY OVERVALUED and OVERBOUGHT! US Stock Market is a MEGA BUBBLE right now!!!
    https://finance.yahoo.com/news/gm-os-jeremy-grantham-warns-the-stock-market-is-in-a-fullyfledged-epic-bubble-185722585.html
    $AMD $NVDA $AMZN $AAPL $SQ $SHOP $SNAP $TWLO $CRM $ROKU $ADBE $DB $BAC $JPM $MS $GS $TWTR $TSLA $IBM $INTC $MSFT $GOOG $LMT $BA $TXN $NXPI $LRCX $NKE $DIS $EBAY $X $MA $V $S $T $F $GM $NFLX $CSCO $CAT $MMM $SBUX $TGT $WMT $ATVI $EA $TTWO $MCD $AVGO $JNJ $BIDU $BZUN $BABA $MU $AMAT $QCOM $WFC $BBBY $PFE $GE $WDC $BLK $KO $UA $ABBV $GILD $BB $ORCL $RH $KEM $IQ $GRPN $PYPL $MA $MOMO $JD $WBA $CVS $FB $W $BBY $SKX $FL $EFX $ETSY $W $UNH $SAP $GPRO $KHC $DPZ $PEP $LYFT $UBER $BYND $ZM $OLED $XOM $CVX $DAL $UAL $AAL $LUV $SAVE $AXP $SPCE $NCLH $CCL $NKLA $NIO $ZM $XPEV $QS
    “The long, long bull market since 2009 has finally matured into a fully-fledged epic bubble,” says GMO’s Jeremy Grantham.
    “The long, long bull market since 2009 has finally matured into a fully-fledged epic bubble,” says GMO’s Jeremy Grantham.
    finance.yahoo.com
  • T
    The US Stock BUBBLE 2020
    $^IXIC conversation
    FINANCIAL CRISIS IS COMING!!! US STOCKS WILL COLLAPSE BIG TIME!
    A HEAVY CORRECTION IS IMMINENT! The US Stocks are EXTREMELY OVERVALUED and OVERBOUGHT!
    SELL ALL US Stocks in this TULIP MANIA BUBBLE!
    INFLATION IS SKYROCKETING as the FED continues to PUMP the Price of everything, stocks, oil, gold, home, land, commodities, utilities, food prices and everything!
    The World Economy is Collapsing, people are starving, but the US Market Makers are too busy in printing money and PUMPING the Stock prices Artificially to make insiders trillionaire without working!
    Enjoy Free Capital Gains in the US Stock Market while the Corporate Revenues are tanking and the Economy is Collapsing! US Stock Market is a “GET QUICK RICH” Scheme!
    Dow Jones Industrial Average (^DJI) was 17,000 in 2016, with better economic fundamentals and higher corporate earnings. However, thanks to the Collapsing Economy, Coronavirus Pandemic, Tanking Corporate revenues and earnings, Skyrocketing unemployment, Trade Wars, Record INFLATION levels, and Heavy Stock Dilutions, Dow Jones Industrial Average (^DJI) BUBBLE has almost Doubled!
    S&P 500 (^GSPC) was at 1600.00 with better fundamentals and higher corporate earnings in 2016. Now it is sitting at ABSURD 3700.00 with TERRIBLE Fundamentals, Collapsing Economy, HEAVIER Corporate and National Debt and way lower corporate revenues and earnings!
    The World Countries are refusing to accept the US Dollar as international reserve currency due to the HEAVY Dollar PRINTING!
    US Stocks are INSANELY OVERVALUED and OVERBOUGHT! US Stock Market is a MEGA BUBBLE right now!!!
    $AMD $NVDA $AMZN $AAPL $SQ $SHOP $SNAP $TWLO $CRM $ROKU $ADBE $DB $BAC $JPM $MS $GS $TWTR $TSLA $IBM $INTC $MSFT $GOOG $LMT $BA $TXN $NXPI $LRCX $NKE $DIS $EBAY $X $MA $V $S $T $F $GM $NFLX $CSCO $CAT $MMM $SBUX $TGT $WMT $ATVI $EA $TTWO $MCD $AVGO $JNJ $BIDU $BZUN $BABA $MU $AMAT $QCOM $WFC $BBBY $PFE $GE $WDC $BLK $KO $UA $ABBV $GILD $BB $ORCL $RH $KEM $IQ $GRPN $PYPL $MA $MOMO $JD $WBA $CVS $FB $W $BBY $SKX $FL $EFX $ETSY $W $UNH $SAP $GPRO $KHC $DPZ $PEP $LYFT $UBER $BYND $ZM $OLED $XOM $CVX $DAL $UAL $AAL $LUV $SAVE $AXP $SPCE $NCLH $CCL $NKLA $NIO $ZM $XPEV $QS
    https://www.businessinsider.com/national-debt-problem-of-free-money-stimulus-checks-covid-relief-2021-1?r=DE&IR=T
    The debt crisis in the US is similar to global warming — it is an incremental but enormous phenomenon that could trigger disaster at any given point.
    The debt crisis in the US is similar to global warming — it is an incremental but enormous phenomenon that could trigger disaster at any given point.
    www.businessinsider.com
  • I
    INFLATION is SKYROCKETING
    $^FTSE conversation
    FINANCIAL CRISIS IS COMING!!! US STOCKS WILL COLLAPSE BIG TIME!
    A HEAVY CORRECTION IS IMMINENT! The US Stocks are EXTREMELY OVERVALUED and OVERBOUGHT!
    SELL ALL US Stocks in this TULIP MANIA BUBBLE!
    INFLATION IS SKYROCKETING as the FED continues to PUMP the Price of everything, stocks, oil, gold, home, land, commodities, utilities, food prices and everything!
    The World Economy is Collapsing, people are starving, but the US Market Makers are too busy in printing money and PUMPING the Stock prices Artificially to make insiders trillionaire without working!
    Enjoy Free Capital Gains in the US Stock Market while the Corporate Revenues are tanking and the Economy is Collapsing! US Stock Market is a “GET QUICK RICH” Scheme!
    Dow Jones Industrial Average (^DJI) was 17,000 in 2016, with better economic fundamentals and higher corporate earnings. However, thanks to the Collapsing Economy, Coronavirus Pandemic, Tanking Corporate revenues and earnings, Skyrocketing unemployment, Trade Wars, Record INFLATION levels, and Heavy Stock Dilutions, Dow Jones Industrial Average (^DJI) BUBBLE has almost Doubled!
    S&P 500 (^GSPC) was at 1600.00 with better fundamentals and higher corporate earnings in 2016. Now it is sitting at ABSURD 3700.00 with TERRIBLE Fundamentals, Collapsing Economy, HEAVIER Corporate and National Debt and way lower corporate revenues and earnings!
    The World Countries are refusing to accept the US Dollar as international reserve currency due to the HEAVY Dollar PRINTING!
    US Stocks are INSANELY OVERVALUED and OVERBOUGHT! US Stock Market is a MEGA BUBBLE right now!!!
    $AMD $NVDA $AMZN $AAPL $SQ $SHOP $SNAP $TWLO $CRM $ROKU $ADBE $DB $BAC $JPM $MS $GS $TWTR $TSLA $IBM $INTC $MSFT $GOOG $LMT $BA $TXN $NXPI $LRCX $NKE $DIS $EBAY $X $MA $V $S $T $F $GM $NFLX $CSCO $CAT $MMM $SBUX $TGT $WMT $ATVI $EA $TTWO $MCD $AVGO $JNJ $BIDU $BZUN $BABA $MU $AMAT $QCOM $WFC $BBBY $PFE $GE $WDC $BLK $KO $UA $ABBV $GILD $BB $ORCL $RH $KEM $IQ $GRPN $PYPL $MA $MOMO $JD $WBA $CVS $FB $W $BBY $SKX $FL $EFX $ETSY $W $UNH $SAP $GPRO $KHC $DPZ $PEP $LYFT $UBER $BYND $ZM $OLED $XOM $CVX $DAL $UAL $AAL $LUV $SAVE $AXP $SPCE $NCLH $CCL $NKLA $NIO $ZM $XPEV $QS
    https://www.businessinsider.com/national-debt-problem-of-free-money-stimulus-checks-covid-relief-2021-1?r=DE&IR=T
    The debt crisis in the US is similar to global warming — it is an incremental but enormous phenomenon that could trigger disaster at any given point.
    The debt crisis in the US is similar to global warming — it is an incremental but enormous phenomenon that could trigger disaster at any given point.
    www.businessinsider.com
  • A
    ABSURD Company Valuations 2021
    $^FTSE conversation
    EU MARKETS ARE COLLAPSING! The US Stock BUBBLE will FOLLOW!
    The US Stocks are EXTREMELY OVERVALUED and OVERBOUGHT!
    SELL ALL US Stocks in this TULIP MANIA BUBBLE! The Valuations are ABSURD and IMPOSSIBLE TO JUSTIFY!
    INFLATION IS SKYROCKETING as the FED continues to PUMP the Price of everything, stocks, oil, gold, home, land, commodities, utilities, food prices and everything!
    The World Economy is Collapsing, people are starving, but the US Market Makers are too busy in printing money and PUMPING the Stock prices Artificially to make insiders trillionaire without working!
    Enjoy Free Capital Gains in the US Stock Market while the Corporate Revenues are tanking and the Economy is Collapsing! US Stock Market is a “GET QUICK RICH” Scheme!
    Dow Jones Industrial Average (^DJI) was 17,000 in 2016, with better economic fundamentals and higher corporate earnings. However, thanks to the Collapsing Economy, Coronavirus Pandemic, Tanking Corporate revenues and earnings, Skyrocketing unemployment, Trade Wars, Record INFLATION levels, and Heavy Stock Dilutions, Dow Jones Industrial Average (^DJI) BUBBLE has almost Doubled!
    S&P 500 (^GSPC) was at 1600.00 with better fundamentals and higher corporate earnings in 2016. Now it is sitting at ABSURD 3800.00 with TERRIBLE Fundamentals, Collapsing Economy, HEAVIER Corporate and National Debt and way lower corporate revenues and earnings!
    The World Countries are refusing to accept the US Dollar as international reserve currency due to the HEAVY Dollar PRINTING!
    US Stocks are INSANELY OVERVALUED and OVERBOUGHT! US Stock Market is a MEGA BUBBLE right now!!!
    https://edition.cnn.com/2020/05/01/investing/stock-market-recession-coronavirus/index.html
    $AMD $NVDA $AMZN $AAPL $SQ $SHOP $SNAP $TWLO $CRM $ROKU $ADBE $DB $BAC $JPM $MS $GS $TWTR $TSLA $IBM $INTC $MSFT $GOOG $LMT $BA $TXN $NXPI $LRCX $NKE $DIS $EBAY $X $MA $V $S $T $F $GM $NFLX $CSCO $CAT $MMM $SBUX $TGT $WMT $ATVI $EA $TTWO $MCD $AVGO $JNJ $BIDU $BZUN $BABA $MU $AMAT $QCOM $WFC $BBBY $PFE $GE $WDC $BLK $KO $UA $ABBV $GILD $BB $ORCL $RH $KEM $IQ $GRPN $PYPL $MA $MOMO $JD $WBA $CVS $FB $W $BBY $SKX $FL $EFX $ETSY $W $UNH $SAP $GPRO $KHC $DPZ $PEP $LYFT $UBER $BYND $ZM $OLED $XOM $CVX $DAL $UAL $AAL $LUV $SAVE $AXP $SPCE $NCLH $CCL $NKLA $NIO $ZM $XPEV $QS
    The coronavirus pandemic has exposed a gaping disconnect between unprecedented economic pain on Main Street and extreme optimism on Wall Street.
    The coronavirus pandemic has exposed a gaping disconnect between unprecedented economic pain on Main Street and extreme optimism on Wall Street.
    edition.cnn.com
  • R
    Record High Inflation
    $^FTSE conversation
    SELL ALL US STOCKS BEFORE A MAJOR COLLAPSE! FINANCIAL CRISIS IS COMING!
    INFLATION IS SKYROCKETING! THE FED MUST RAISE THE RATES!
    The US Stocks are EXTREMELY OVERVALUED and OVERBOUGHT!
    SELL ALL US Stocks in this TULIP MANIA BUBBLE! The Valuations are ABSURD and IMPOSSIBLE TO JUSTIFY!
    INFLATION IS SKYROCKETING as the FED continues to PUMP the Price of everything, stocks, oil, gold, home, land, commodities, utilities, food prices and everything!
    The World Economy is Collapsing, people are starving, but the US Market Makers are too busy in printing money and PUMPING the Stock prices Artificially to make insiders trillionaire without working!
    Enjoy Free Capital Gains in the US Stock Market while the Corporate Revenues are tanking and the Economy is Collapsing! US Stock Market is a “GET QUICK RICH” Scheme!
    Dow Jones Industrial Average (^DJI) was 17,000 in 2016, with better economic fundamentals and higher corporate earnings. However, thanks to the Collapsing Economy, Coronavirus Pandemic, Tanking Corporate revenues and earnings, Skyrocketing unemployment, Trade Wars, Record INFLATION levels, and Heavy Stock Dilutions, Dow Jones Industrial Average (^DJI) BUBBLE has almost Doubled!
    S&P 500 (^GSPC) was at 1600.00 with better fundamentals and higher corporate earnings in 2016. Now it is sitting at ABSURD 3800.00 with TERRIBLE Fundamentals, Collapsing Economy, HEAVIER Corporate and National Debt and way lower corporate revenues and earnings!
    The World Countries are refusing to accept the US Dollar as international reserve currency due to the HEAVY Dollar PRINTING!
    US Stocks are INSANELY OVERVALUED and OVERBOUGHT! US Stock Market is a MEGA BUBBLE right now!!!
    $AMD $NVDA $AMZN $AAPL $SQ $SHOP $SNAP $TWLO $CRM $ROKU $ADBE $DB $BAC $JPM $MS $GS $TWTR $TSLA $IBM $INTC $MSFT $GOOG $LMT $BA $TXN $NXPI $LRCX $NKE $DIS $EBAY $X $MA $V $S $T $F $GM $NFLX $CSCO $CAT $MMM $SBUX $TGT $WMT $ATVI $EA $TTWO $MCD $AVGO $JNJ $BIDU $BZUN $BABA $MU $AMAT $QCOM $WFC $BBBY $PFE $GE $WDC $BLK $KO $UA $ABBV $GILD $BB $ORCL $RH $KEM $IQ $GRPN $PYPL $MA $MOMO $JD $WBA $CVS $FB $W $BBY $SKX $FL $EFX $ETSY $W $UNH $SAP $GPRO $KHC $DPZ $PEP $LYFT $UBER $BYND $ZM $OLED $XOM $CVX $DAL $UAL $AAL $LUV $SAVE $AXP $SPCE $NCLH $CCL $NKLA $NIO $ZM $XPEV $QS
    https://finance.yahoo.com/quote/%5ETNX?p=%5ETNX
    Find the latest information on CBOE Interest Rate 10 Year T No (^TNX) including data, charts, related news and more from Yahoo Finance
    Find the latest information on CBOE Interest Rate 10 Year T No (^TNX) including data, charts, related news and more from Yahoo Finance
    finance.yahoo.com
  • A
    Art
    $ENZC conversation
    ENZC and ViiV Healthcare are in business!!! A True OMG!

    Guess who owns ViiV???

    Google Answers, and The name Pfizer $PFE shows up! Are you kidding The Rock!!!!! What is this Disney Land??!!!! I’m feeling dizzy just thinking about what’s to come out of this. Can you say OMG
    🚀🚀
  • W
    WarrenIsMyMentor
    WHY DSUVIA over say $TRVN IV Oli or $PFE Morphine both invasive pain medications; AVOID IVs, w/ DSUVIA the world's only NON INVASIVE & RAPID Acute Pain medication in the WORLD. IV risks:
    - "Deep vein thrombosis is one type of dangerous blood clot that IV treatment can cause."
    - "If air gets into the syringe or the IV medication bag and the line runs dry, air bubbles can enter your vein. These air bubbles can then travel to your heart or lungs and block your blood flow. An air embolism can cause severe problems such as heart attack or stroke."
    - "Infection can occur at the injection site."
    - "A vein can be damaged during injection or by the use of an IV catheter line. This can cause infiltration. When this occurs, medication leaks into surrounding tissue instead of going into the bloodstream. Infiltration can cause tissue damage."
    - "IV's can cause vein damage by way of misplacement, duration of the IV within the venous system, or by the nature of medication in which they are delivering."
    - "IV bolus medications may cause a sudden drop in blood pressure or heart rate, or hives may result."
  • c
    chester
    Bought 5000k $PFE $34.85
    PT $45
    The vaccine contributed $154 million of the company's $11.7 billion in sales during the fourth quarter, helping lift the company's overall revenue from all vaccines to $2 billion, a 17% year-over-year increase.

    Pfizer projects the vaccine's impact will be considerable this year, becoming one of the company's top-selling products. In 2021, Pfizer expects full-year revenue of between $59.4 billion and $61.4 billion, and adjusted earnings of between $3.10 and $3.20 a share.
  • S
    Shaw
    Just heard Warren Buffet is dumping $PFE $AAPL $GM $JPM
  • A
    Alchemist
    Pfizer earnings tomorrow Before Open. I really hope $PFE review partner ATRS products. Take cover
  • S
    Simon
    $ATRS conversation
    Maybe Otrexup will get a boost for Rheumatoid Arthritis from Pfizers' failure in safety study for JAK Inhibitor Xeljenz--> see below:
    Pfizer's big blockbuster Xeljanz flunks its post-marketing safety study, renewing harsh questions for JAK class
    Jason Mast
    Editor

    When the FDA approved Pfizer’s JAK inhibitor Xeljanz for rheumatoid arthritis in 2012, they slapped on a black box warning for a laundry list of adverse events and required the New York drugmaker to run a long-term safety study.

    That study has since become a consistent headache for Pfizer and their blockbuster molecule. Last year, Pfizer dropped the entire high dose cohort after an independent monitoring board found more patients died in that group than in the low dose arm or a control arm of patients who received one of two TNF inhibitors, Enbrel or Humira.

    And on Wednesday, Pfizer announced that the six-year study had failed. Across 4,362 patients, those who received either a low or high dose of Xeljanz experienced more major cardiovascular events — such as stroke and heart attack — than those on Humira or Enbrel. They also had higher rates of cancer, with Pfizer failing to hit non-inferiority on both primary endpoints.

    Key questions, such as differences in mortality, have yet to be answered. Still, the study renews difficult questions for a class of drugs that has generated significant efficacy in autoimmune conditions but faced continual safety concerns. The FDA put black box warnings on both Xeljanz and Eli Lilly’s Olumiant and last year rejected Gilead’s filgotinib outright, ending the big biotech’s plan to develop the drug in the US.

    A Pfizer spokesperson noted in an email that, unlike in previous Xeljanz trials, participants in the latest study had to be over the age of 50 and have at least one cardiovascular risk factor. He said they were “continuing to evaluate the findings of this study” and will work with the FDA to review the full results.

    “At this point we cannot speculate on hypothetical market impact,” he said.

    An FDA spokesperson similarly demurred but said they would review adverse event reports and any other data sent to the agency.

    “We cannot speculate on whether labeling changes will be made for Pfizer’s Xeljanz,” he said.

    Investors, though, were quick to speculate about the impact for Pfizer $PFE, shaving 2.3% off its stock Thursday morning, or nearly $5 billion of market cap. Xeljanz has become essential to Pfizer’s portfolio as the New York pharma tries to double down on its pipeline, bringing $654 million in Q3 2020 alone.

    It’s also not yet clear how the new findings will impact JAK inhibitors more broadly. In a note to investors, RBC’s Brian Abrahams said physicians already take safety issues into account when considering JAK inhibitors, but that the new data could make the FDA “even more risk-averse on labeling for the class going forward.” That could impact Incyte as they await the FDA’s decision on a topical formulation for Jakafi, one of the only JAK inhibitors that does not yet have a black box warning.

    Meanwhile, Gilead’s decision to bail on filgotinib now appears prudent, he said, and newer, non-JAK approaches for autoimmune diseases could now gain steam.

    “Greater baggage on Xeljanz and JAK class could keep door open for other anti-inflammatory approaches in diseases like RA, psoriatic arthritis, and IBD, and benefit co’s pursuing such approaches,” Abrahams said, singling out Galapagos’ Toledo program of SIK inhibitors.

    The Pfizer study compared rheumatoid arthritis patients who received either 10mg Xeljanz, 5 mg Xeljanz or Humira, with just under 1,500 patients assigned to each group.

    In raw numbers, Xeljanz high and low dose patients had 51 and 47 cardiovascular events, compared with 37 for patients on Humira. When calculated as a percentage of person-years — a metric that simply adds up the total number of years each patient has been on the therapy — patients on Xeljanz saw 0.98 events per 100 years, compared with 0.73 events for Humira. That amounts to a 33% difference.

    For malignancies, Xeljanz patients saw 1.13 events per 100 years, compared to 0.77 events for cancer — a 47% difference.

    Although Pfizer had altered the study last year over concerns about mortality in the high dose, the company said there was no statistically significant difference between the two Xeljanz doses on either primary endpoint. Pfizer, though, said they are still collecting and analyzing data on differences in mortality and another major adverse event, pulmonary embolism.
  • T
    Tommy H
    $OCGN conversation
    Better buckle up before the open. Upgrades point north Started at $4 now up to $13. Love this OCGN more than $PFE or $JNJ
  • S
    Shaw
    How come $PFE didn’t get anything out of POTUS visit at site on Friday in Michigan?
  • T
    Truth
    $MRNA conversation
    Most valuable Covid Vaccine stocks --- 1) $MRNA 2) $PFE
  • D
    Duckula
    $AMC conversation
    The same basher 'Michael' is also over on $pfe bashing it, and a bunch of other stocks if you click on him. Paid bashers with many id's. Report them all.
  • N
    NorInvest
    $BNTX conversation
    Is $PFE talking about their piece of the revenue? Or both Pfe and BNTX combined? If they estimate 15B$ in 2021 from the Covid vaccine and its 50% of the total then 30B$ revenue it’s a great estimate. If its the total its not super great.